Наукові публікації університету

Infectious Complications of Acute Pancreatitis Is Associated with Peripheral Blood Phagocyte Functional Exhaustion

Background Infected pancreatic necrosis is one of the most severe complications of acute pancreatitis (AP). The development of secondary infection doubles the risk of death during the late stage of necrotizing pancreatitis. Phagocytes play a major role in AP pathogenesis, as well as in local and systemic complications of the disease.
Aims We aimed to investigate the relationship between quantitative and functional indices of circulating phagocyte at the time of admission and onset of infectious complications in patients with AP afterward.
Methods A post hoc analysis of 97 patients with AP was conducted. The metabolic state of peripheral blood neutrophils and monocytes was analyzed based on their phagocytic activity and generation of reactive oxygen species (ROS), which were determined by flow cytometry on admission. The clinical end point was marked by onset of infectious complications of AP.
Results On admission, baseline values and reactivity reserve of monocyte and neutrophil phagocytic activity in AP patients, who developed septic complications, were substantially decreased, whereas monocyte ROS generation was dramatically increased as compared to the group without infectious processes. ROC curve was obtained both for neutrophil and monocyte phagocytosis reactivity reserve expressed as modulation coefficient values and categorized as the risk factor of infectious complications, showing an area under curve of 0.95 (P < 0.0001) and 0.84 (P < 0.0001), respectively.
Conclusions Early (at the time of admission) detection of quantitative and functional indices of circulating phagocytes can be useful for the prediction of septic complications in SAP patients.

ID: 244411
Кількість показів: 33
дата змінення: 19.03.2020 16:08:44
Ким змінено (ім'я): (bio_36) Марія Рудик
Вид роботи:  Наукова публікація
Тип роботи:  Наукова стаття
Кількість сторінок:  9
Рік видання:  2020
Звітний рік:  2020
Видання:  Digestive Diseases And Sciences
Галузь науки:  Імунологія
Автори,співробітники Університету:  Сківка Лариса Михайлівна
Автори зовнішні:  Федорчук Олександр Григорович /  Сусак Ярослав Михайлович  / Дирда О. О. / Ткаченко Олександр
Кафедра / Відділ:  Кафедра мікробіології та імунології
Посилання на статтю (посилання на рецензію в журналі (для монографій):  https://doi.org/10.1007/s10620-020-06172-y
Ключові слова:  Acute pancreatitis · Phagocytes · Phagocytosis · Reactivity reserve
Опубліковано за рішенням Вченої ради:  ні
Інститут/Факультет:  ННЦ "Інститут біології та медицини"

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